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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN1
All Species:
35.45
Human Site:
Y152
Identified Species:
78
UniProt:
P18031
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P18031
NP_002818.1
435
49967
Y152
I
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
Chimpanzee
Pan troglodytes
XP_512196
415
48479
Y153
L
S
E
D
V
K
S
Y
Y
T
V
H
L
L
Q
Rhesus Macaque
Macaca mulatta
XP_001096290
435
49928
Y152
I
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
Dog
Lupus familis
XP_534455
424
48717
Y152
I
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
Cat
Felis silvestris
Mouse
Mus musculus
P35821
432
49575
Y152
I
S
E
D
V
K
S
Y
Y
T
V
R
Q
L
E
Rat
Rattus norvegicus
P20417
432
49656
Y152
I
S
E
D
V
K
S
Y
Y
T
V
R
Q
L
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508429
545
61767
Y154
I
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
Chicken
Gallus gallus
O13016
434
50316
Y152
I
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
Frog
Xenopus laevis
NP_001086085
428
49306
Y154
L
S
E
D
I
K
S
Y
Y
T
I
R
Q
L
M
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W0G1
548
62086
N174
V
R
L
E
T
Y
Q
N
F
V
R
R
W
F
K
Honey Bee
Apis mellifera
XP_392429
495
55903
D167
I
S
K
T
E
S
S
D
Y
T
T
R
I
L
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
54
97.6
88.5
N.A.
82.9
84.3
N.A.
58.1
78.1
70.8
N.A.
N.A.
34.1
40
N.A.
N.A.
Protein Similarity:
100
69.8
99
92.8
N.A.
90.5
90.8
N.A.
66.2
86.9
82.3
N.A.
N.A.
49.4
57.1
N.A.
N.A.
P-Site Identity:
100
66.6
100
100
N.A.
93.3
93.3
N.A.
100
100
80
N.A.
N.A.
6.6
46.6
N.A.
N.A.
P-Site Similarity:
100
86.6
100
100
N.A.
100
100
N.A.
100
100
93.3
N.A.
N.A.
33.3
60
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
82
0
0
0
10
0
0
0
0
0
0
0
% D
% Glu:
0
0
82
10
10
0
0
0
0
0
0
0
0
0
64
% E
% Phe:
0
0
0
0
0
0
0
0
10
0
0
0
0
10
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% H
% Ile:
73
0
0
0
55
0
0
0
0
0
10
0
10
0
0
% I
% Lys:
0
0
10
0
0
82
0
0
0
0
0
0
0
0
19
% K
% Leu:
19
0
10
0
0
0
0
0
0
0
0
0
10
91
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% M
% Asn:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
10
0
0
0
0
0
73
0
10
% Q
% Arg:
0
10
0
0
0
0
0
0
0
0
10
91
0
0
0
% R
% Ser:
0
91
0
0
0
10
91
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
10
10
0
0
0
0
91
10
0
0
0
0
% T
% Val:
10
0
0
0
28
0
0
0
0
10
73
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% W
% Tyr:
0
0
0
0
0
10
0
82
91
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _